Archive for category: Social Science Homework Help

Importance of Becoming a Global Citizen

[WLOs: 1, 2, 3, 4, 5] [CLOs: 1, 2, 3, 4, 5]

Prepare: View the Globalization at a Crossroads (Links to an external site.)Links to an external site. series episode and read the article A Model of Global Citizenship: Antecedents and Outcomes by Stephen Reysen and Iva Katzarska-Miller (2013). Go to the Ashford University Library, and locate one additional source on global citizenship that will help support your viewpoint.

Reflect: Please take some time to reflect on how the concept of global citizenship has shaped your identity, and think about how being a global citizen has made you a better person in your community.

Write: Use the Week 1 Example Assignment Guide when addressing the following prompts:

• Describe and explain a clear distinction between “globalism” and “globalization” after viewing the video and reading the article.
• Describe how being a global citizen in the world of advanced technology can be beneficial to your success in meeting your personal, academic, and professional goals.
• Explain why there has been disagreement between theorists about the definition of global citizenship and develop your own definition of global citizenship after reading the article by Reysen and Katzarska-Miller.
• Choose two of the six outcomes of global citizenship from the article (i.e., intergroup empathy, valuing diversity, social justice, environmental sustainability, intergroup helping, and the level of responsibility to act for the betterment of this world).
  • Explain why those two outcomes are the most important in becoming a global citizen compared to the others.
• Describe at least two personal examples or events in your life that illustrate the development of global citizenship based on the two outcomes you chose.
• Identify two specific general education courses.
  • Explain how each course influenced you to become a global citizen.

The Importance of Becoming a Global Citizen

• Must be 750 to 1,000 words in length (not including title and references pages) and formatted according to APA style, as outlined
• Must include a separate title page with the following:
  • Title of paper
  • Student’s name
  • Course name and number
  • Instructor’s name
  • Date submitted
• For further assistance with the formatting and the title page, refer to APA Formatting for Word 2013 (Links to an external site.)Links to an external site..
• Must utilize academic voice. See the Academic Voice (Links to an external site.)Links to an external site. resource for additional guidance.
• Must include an introduction and conclusion paragraph. Your introduction paragraph needs to end with a clear thesis statement that indicates the purpose of your paper.
• Must use at least one credible source in addition to the two required sources (video and article).
  • The Scholarly, Peer Reviewed, and Other Credible Sources (Links to an external site.)Links to an external site. table offers additional guidance on appropriate source types. If you have questions about whether a specific source is appropriate for this assignment, contact your instructor. Your instructor has the final say about the appropriateness of a specific source for an assignment. The Integrating Research (Links to an external site.)Links to an external site. tutorial will offer further assistance with including supporting information and reasoning.
• Must document in APA style any information used from sources, as outlined in the Ashford Writing Center’s In-Text Citation Guide (Links to an external site.)Links to an external site..
• Must have no more than 15% quoted material in the body of your essay based on the Turnitin report. References list will be excluded from the Turnitin originality score.
• Must include a separate references page that is formatted according to APA style. See the Formatting Your References List (Links to an external site.)Links to an external site.

Before you submit your written assignment, you are encouraged to review the review the Grammarly (Links to an external site.)Links to an external site. page tutorial, set up a Grammarly account (if you have not already done so), and use Grammarly to review a rough draft of your assignment. Then carefully review all issues identified by Grammarly and revise your work as needed.

TWO FILMS

Globalization at a crossroads: https://fod.infobase.com/OnDemandEmbed.aspx?token=…

must use at least one credible source in addition to the two required sources (video and article): https://content.bridgepointeducation.com/curriculu…

Week 1 EXAMPLE ASSIGNMENT GUIDE: Uploaded

Use the following Case Scenario, Subjective Data, and Objective Data to answer the Critical Thinking Questions.

Case Scenario

Mrs. J. is a 63-year-old woman who has a history of hypertension, chronic heart failure, and sleep apnea. She has been smoking two packs of cigarettes a day for 40 years and has refused to quit. Three days ago, she had an onset of flu with fever, pharyngitis, and malaise. She has not taken her antihypertensive medications or her medications to control her heart failure for 4 days. Today, she has been admitted to the hospital ICU with acute decompensated heart failure.

Subjective Data

1. Is very anxious and asks whether she is going to die.
2. Denies pain but says she feels like she cannot get enough air.
3. Says her heart feels like it is “running away.”
4. Reports that she is so exhausted she cannot eat or drink by herself.

Objective Data

1. Height 175 cm; Weight 95.5 kg
2. Vital signs: T 37.6 C, HR 118 and irregular, RR 34, BP 90/58
3. Cardiovascular: Distant S1, S2, S3 present; PMI at sixth ICS and faint; all peripheral pulses are 1+; bilateral jugular vein distention; initial cardiac monitoring indicates a ventricular rate of 132 and atrial fibrillation
4. Respiratory: Pulmonary crackles; decreased breath sounds right lower lobe; coughing frothy blood-tinged sputum; SpO2 82%
5. Gastrointestinal: BS present: hepatomegaly 4 cm below costal margin

Critical Thinking Questions

What nursing interventions are appropriate for Mrs. J. at the time of her admission? Drug therapy is started for Mrs. J. to control her symptoms. What is the rationale for the administration of each of the following medications?

1. IV furosemide (Lasix)
2. Enalapril (Vasotec)
3. Metoprolol (Lopressor)
4. IV morphine sulphate (Morphine)

Describe four cardiovascular conditions that may lead to heart failure and what can be done in the form of medical/nursing interventions to prevent the development of heart failure in each condition.

Taking into consideration the fact that most mature adults take at least six prescription medications, discuss four nursing interventions that can help prevent problems caused by multiple drug interactions in older patients. Provide rationale for each of the interventions you recommend.

Question 1

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The ATP1A2 gene codes for the Na+,K+-ATPase aka the sodium potassium pump which is required in neurons for nerutransmissions involving propagated alterations in membrane potential. The Na+,K+-ATPase is a cation-transporting integral membrane protein involved in active transport of sodium and potassium ions against their concentration gradients across the cell membrane. For every molecule of ATP consumed, three sodium ions are exported from the cell in exchange for import of two potassium ions. The Na+,K+-ATPase serves many roles, including cell-volume homeostasis as well as maintenance of the membrane potential. In addition, the generated Na+ and K+ gradients drive various secondary active transporters. Since transport of Na+ and K+ across the cell membrane takes place against such steep concentration gradients, the enzyme consumes high amounts of energy: approximately 25–50% of cellular ATP is consumed by the Na+,K+-ATPase .

Mutations in the ATP1A2 gene have been determined to be one the causes of Familial hemiplegic migraine types 1 and 2…..FHM & FHM2. Recent reports have suggested that patients with mutated ATP1A2 genes may be getting these migraines due to “synaptic fatigue” caused directly or indirectly by the mutated Na/K pump. In these cases neuron to neuron synapses require pre-synaptic glutamate release and require glutamate binding to triggered channels (AMPA) on the post synapse leading to channel opening; letting Na+ into the post synaptic cell and also fostering Ca+2 entry via Nmda receptors. It is after these steps that “synaptic fatigue” potentially might occur at the presynaptic membrane due to the mutated Na/K pumps within the synapse region leading to migraines.

A. Hypothetically suggest “in detailed description” two (2) possible models that would explain how defects/changes in the amino acid sequence of the Na+,K+-ATPase membrane protein (due to mutation in the gene) might result in “synaptic fatigue”. In at least one of these 2 proposed models explain how the mutant Na/K pump together with normal synaptic localized Astrocyte activity might be co-involved in causing the abnormal outcome of chronic “synaptic fatigue” associated with and exhibited in these FHM patients. (hint look up role of astrocytes at synapses that release glutamate)

B. Suggest an experiment or experiments to validate or falsify your hypothesis…for one of your posited models.

Question 2

You are interested in understanding how the neuromuscular junction works. (see figure 11-39–5th ed)

Normally glutamate binding at the post synaptic membrane leads to post synaptic membrane deploarization via Na+ entry into the muscle cell at the Acetylcholine gated cation channel which propagates to nearby voltage-gated Na+ channels leading to more Na entry. As the action potential propagates away from the channel and down the t tubles it ultimately causes Ca+ release from the smooth ER which then Ca+ binds troponin C leading to actin-myosin II contractions of muscle

The normal post synaptic voltage-gated Na+ channel in the muscle cell membrane that responds to the depolarization caused by Na entry at the Acetylcholine gated cation channel typically has the action potential characteristics depicted by the solid red line in (figure 11-29–5th ed). In an experiment of your design you decide to replace this normal voltage gated Na+ channel with a mutant voltage-gated Na+ channel…..coded for by a mutant SCN1A gene

In your experiment you test and discover that this mutated voltage-gated Na+ channel can bind to Na+ ions with equal affinity as the wildtype gated Na+ channel. But when the mutated post synaptic voltage-gated Na+ channel’s membrane potential is measured after adding acetylcholine it only reaches +20mV at 0.5 ms (30mV below the normal Channel’s max level at that time) (see figure 11-29–5th ed) and its downstream propagated depolarization event is severely delayed and hence triggers Calcium release from the smooth ER ….50ms….. later than normal.(see figure 11-30 and 11-39–5th ed)

A. What might have this mutation done to the Na+ channel to alter its ability to reach a max positive membrane potential of +50mV at 0.5 ms. also Based on your previous answer to A. …How and why would this then delay the “continued” propagation of the “next wave” of depolarization needed for Calcium release from the sarcoplasmic reticulim (SER)

B. If we use a lot more, acetylcholine to bind to and open the Acetylcholine gated cation channel at the synapse[see figure 11-39] could this somehow alter the action potential generated by the adjacent mutated voltage gated Na+ channel returning it to normal max membrane potential levels of 50mV levels at 0.5 ms and -20mV levels at 1ms? (see figure 11-29 and 11-30)

C. What clinical effect will this mutation in the voltage gated Na+ channel gene have on a patient regarding them controlling their own skeletal muscles for movement, or controlling the beating of their heart? (chapter 11 but also chapter 15 —see differential effects of acetylcholine ligands on different targets)

Chapter 15

Question 3

You are interested in the function of a protein, Mtm1, that has a PH domain, an SH3 domain, and a PTB domain. Mtm1 functions downstream of the insulin receptor and binds to this receptor in an insulin-dependent fashion via its PTB domain. You create mutant forms of Mtm1 that delete the various protein domains. You find that these mutations do not seem to affect the protein level or folding of Mtm1. You examine the localization of Mtm1 and your results are summarized in Table Q15-2.

In Table Q15-2, the Δ symbol indicates that the following protein domain is deleted. For example, mtm1ΔPH indicates an Mtm1 protein that lacks the PH domain; mtm1ΔPHΔSH3 indicates an mtm1 protein that lacks both the PH domain and the SH3 domain.

A. Given what you know about these three protein domains and the data above, explain the role of the PH, PTB, and SH3 domains in localizing the Mtm1 protein.

B. How might mutating the insulin receptor within its kinase domain impact the localization of the Mtm1 protein….assume the mutant kinase domain is completely non functional

C. Based on the data in the table which mutation would effect Mtm1s normal localization more….mutating the insulin receptor within its kinase domain or mutating a PI-3 kinase within its catalytic domain…..assume both mutants are completely non functional.

D. If we replaced the PTB domains in Mtm1 with SH2 domains how would this change Mtm1s cellular localization process? Would it change …would it stay the same….explain.

Question 4

The olfactory receptor neurons in frogs resemble those of mammals, in that they express olfactory receptors that are coupled to a G protein. When the G protein is activated, it activates an adenylyl cyclase to produce cAMP, which then opens cyclic-AMP gated cation channels in the plasma membrane. The opening of these channels depolarizes the membrane, leading to the production of an action potential. Your friend is interested in why neurons stop responding to an odor after prolonged exposure to it, a process called adaptation. He has conducted experiments examining the depolarization of the olfactory receptor neuron, the binding of odorant to the receptor, the activation of the G protein, the levels of cAMP in the cell, and the phosphorylation of adenylyl cyclase. His results are summarized in Table Q15-6.

A. What conclusions can be drawn from the above data regarding the adaption mechanism?

B. Based on the data in the table….. What effect on smell would be expected if we created frogs that constitutively expressed an active adenyl cyclase phosphatase in their olfactory cells and exposed them to odorant?Would the cells be able to adapt after prolonged exposure ? Why? or Why not?

C. Based on the data in the table….. What effect on smell would be expected if we created frogs that constitutively expressed an active cAMP phosphodiesterase in their olfactory cells and exposed them to odorant?Would the cells be able to adapt after prolonged exposure ? Why? or Why not?

Question 5

Chapter 16

Actin-binding proteins can modify the properties of actin. You purify an actin-binding protein called Abp. You examine the effect of Abp on actin polymerization by measuring the kinetics of in vitro actin filament formation, in which pure actin is added in the presence and the absence of purified Abp protein. You obtain the results shown in Figure Q16-1.

Figure Q16-1

Further experiments show that Abp binds to the side of actin filaments and preferentially binds to ADP-containing actin filaments. Propose a possible molecular mechanism consistent with the data above.

Rough Draft of the Final Report

You are required to develop a rough draft for your Final Lab Report, which covers the drinking water quality experiment from the Week Two Lab assignment “Lab 2: Water Quality and Contamination.” Please use the Week Three Assignment Template for preparing your rough draft to insure that you include all required components in a well-organized manner. Before completing this Template, view the Tutorial on the Rough Draft of the Final Lab Report Template so that you have a clear picture on how to use the template most effectively. This rough draft must also be reviewed using the Grammarly (Links to an external site.)Links to an external site. tool from the Writing Center to help you identify and correct any mistakes to your rough draft. Be sure to submit a screen shot of the Grammarly report and the corrected rough draft to the Week Three Assignment box. This resource will show you how to take a screen shot on your computer and upload it to Waypoint successfully.

For a written transcript, click here.

Complete the following steps to submit both reports:

1. Carefully read the instructions for your Final Lab Report assignment located within Week Five of the course..
2. Download the Rough Draft of the Final Lab Report Template and utilize this form to ensure correct formatting and inclusion of all required material.
3. View the Tutorial on the Rough Draft of the Final Lab Report Template so that you can apply the template with success.
4. Use at least two scholarly sources, two credible sources, and your lab manual to support your points.
5. The rough draft must be three to five pages in length (excluding title and reference pages) and formatted according to APA style. For information regarding APA samples and tutorials, visit the Ashford Writing Center (Links to an external site.)Links to an external site..
6. Use the Grammarly tool to proofread your paper before submitting it for grading. Grammarly is a free proofreading program available to all Ashford students.
   1. To learn how to set up and use Grammarly, watch the Grammarly tutorial (Links to an external site.)Links to an external site..
   2. Upload your paper to Grammarly and take a screen shot of your reviewed paper. Need help taking a screen shot? See this handout.
   3. Save the Grammarly screenshot to your computer and submit it along with your assignment. This means that you will submit two documents to Waypoint: the Grammarly screen shot and your corrected rough draft.

Note: Need help using Grammarly? Email the Writing Center at writing@ashford.edu.

Note: Please do not use www.grammarly.com to sign up as you will get limited feedback. Ashford University pays for additional fabulous Grammarly services so you don’t have to. If you encounter any problems or technical issues, please contact: support@grammarly.com

The Rough Draft of the Final Lab Report must contain the following seven sections in this order:

1. Title Page – This page must include the title of your report, your name, course name, instructor, and date submitted.
2. Introduction – This section should discuss why the experiment was conducted. At a minimum, it should contain three paragraphs. One paragraph must cover background information of similar studies that have already been done in the area. This is accomplished by citing existing literature from similar experiments and explaining their results. A second paragraph should discuss an objective or a reason why the experiment is being done. Why do we want to know the answer to the question we are asking? A third paragraph should provide a hypothesis for the experiment conducted, along with your rationale behind that hypothesis.
3. Materials and Methods – This section should provide a detailed description of the materials used in your experiment and how they were used. A step-by-step rundown of your experiment is necessary; however, it should be done in paragraph form, not in a list format. The description should be exact enough to allow for someone reading the report to replicate the experiment, but it should be in your own words and not simply copied and pasted from the lab manual.
4. Results – This section should include the data and observations from the experiment. All tables and graphs should be present in this section. Additionally, there should be at least one paragraph explaining the data in paragraph form. There should be no personal opinions or discussion beyond the results of your experiments located within this section.
5. Discussion – This section should interpret or explain the meaning of your data and provide conclusions. At least three paragraphs should be outlined here. First, a paragraph should be present that addresses whether your hypothesis was confirmed or denied and how you know this. Second, you are to discuss the meaning of your findings in this area utilizing scholarly sources to put the paper into context. For example, how do your results compare with the findings of similar studies? Also, you should discuss if there are any outside factors (i.e., temperature, contaminants, time of day) that affected your results. If so, how could you control for these in the future? Finally, you should discuss any future questions arising from your results and how you might test them with new experiments.
6. Conclusions – This section should provide a brief summary of your work. What are the key take-away points from your study?
7. References – Provide a list of at least two scholarly sources, two credible sources, and your lab manual that will be used in the Final Lab Report. Format your references according to APA style as outlined in the Ashford Writing Center.

Note: An abstract must be included in the Final Lab Report. However, the abstract should not be included in the rough draft as it is to be written last after the entire paper is fully written. Do not forget this in your Final Lab Report.

In addition to the Grammarly (Links to an external site.)Links to an external site. tool, you have three tutoring services available: Paper Review, Live Chat, and Tutor E-mail. Click on the Writing Center (AWC) tab in the left-navigation menu, in your online course, to learn more about these tutoring options and how to get help with your writing.

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Final Lab Report

You are required to write a complete laboratory report that covers the drinking water quality experiment from “Lab 2: Water Quality and Contamination,” using knowledge gained throughout the course. Use the instructor feedback on your Rough Draft from Week Three to guide your writing. Be sure to download the Final Lab Report Template and utilize this form (not the Rough Draft template) to ensure proper formatting and inclusion of all required material. Additionally, view the Sample Final Lab Report before beginning this assignment, which will illustrate what a Final Lab Report should look like. You must use at least two scholarly sources, two other highly credible sources, and your lab manual to support your points. The report must be six to ten pages in length (excluding the title and reference pages) and formatted according to APA style. For information regarding APA samples and tutorials, visit the Ashford Writing Center, located within the Learning Resources tab on the left navigation toolbar, in your online course.

The Final Lab Report must contain the following eight sections in this order:

1. Title Page – This page must include the title of your report, your name, course name, instructor, and date submitted.
2. Abstract – This section should provide a brief summary of the methods, results, and conclusions. It should allow the reader to see what was done, how it was done, and the results. It should not exceed 200 words and should be the last part written (although it should still appear right after the title page).
3. Introduction – This section should include background information on water quality and an overview of why the experiment was conducted. It should first contain background information of similar studies previously conducted. This is accomplished by citing existing literature from similar experiments. Secondly, it should provide an objective or a reason why the experiment is being done. Why do we want to know the answer to the question we are asking? Finally, it should end the hypothesis from your Week Two experiment, and the reasoning behind your hypothesis. This hypothesis should not be adjusted to reflect the “right” answer. Simply place your previous hypothesis in the report here. You do not lose points for an inaccurate hypothesis; scientists often revise their hypotheses based on scientific evidence following the experiments.
4. Materials and Methods – This section should provide a detailed description of the materials used in your experiment and how they were used. A step-by-step rundown of your experiment is necessary; however, it should be done in paragraph form, not in a list format. The description should be exact enough to allow for someone reading the report to replicate the experiment, however, it should be in your own words and not simply copied and pasted from the lab manual.
5. Results – This section should include the data and observations from the experiment. All tables and graphs should be present in this section. In addition to the tables, you must describe the data in text; however, there should be no personal opinions or discussion outside of the results located within this area.
6. Discussion – This section should interpret your data and provide conclusions. Discuss the meanings of your findings in this area. Was your hypothesis accepted or rejected, and how were you able to determine this? Did the results generate any future questions that might benefit from a new experiment? Were there any outside factors (i.e., temperature, contaminants, time of day) that affected your results? If so, how could you control for these in the future?
7. Conclusions – This section should provide a brief summary of your work.
8. References – List references used in APA format as outlined in the Ashford Writing Center.

In this class, you have three tutoring services available: Paper Review, Live Chat, and Tutor E-mail. Click on the Writing Center (AWC) tab in the left-navigation menu, in your online course, to learn more about these tutoring options and how to get help with your writing

Lesson 4 Discussion

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Group Discussion: Bloodstain pattern analysis is a relatively small facet of forensic science but death investigators often look to these experts to help determine aspects of the crime such as sequence of events, etc. What kinds of implications would happen if bloodstain pattern experts, who vary in training and experience, were wrong in their opinions?

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• Your response should be approximately 200 words in length.